It is estimated that up to 50% of patients with PD may experience some form of depression during the course of their illness. The majority of these individuals experience minor depression. However, major depression can occur roughly in 5% to 10% of cases. Onset of depression or depressive symptoms may pre-date the diagnosis of PD. Early-stage patients may struggle with diagnosis, and this may contribute to symptoms of depression.
Several pharmacological agents are appropriate for treatment of depression in PD patients including:
Aarsland D, Marsh L, Schrag A. Neuropsychiatric symptoms in Parkinson’s disease. Mov Disord. 2009;24(15):2175-2186.