Orthostatic hypotension can affect 20% to 50% of PD patients. It can occur at any stage, but usually is most bothersome in moderate to advanced patients. If occurring early, consider alternative diagnoses such as multiple system atrophy.
Wood LD, Neumiller JL, Setter SM, Dobbins EK. Clinical review of treatment options for select nonmotor symptoms of Parkinson’s disease. Am J Geriatr Pharmacother. 2010;8(4):294-315.
Senard JM, Brefel-Courbon C, Rascol O, Montastruc JL. Orthostatic hypotension in patients with Parkinson’s disease: pathophysiology and management. Drugs Aging. 2001;18(7):495-505.