As all cardinal symptoms in PD (tremor, bradykinesia, rigidity, postural instability), the following motor symptoms are due to loss of dopaminergic neurons:
These symptoms can be present at any stage of the disease but are not specific of PD. Most of these symptoms can be addressed from the moment you start talking to your patient and should be addressed throughout the physical examination.
Ahlskog, JE. Clinical diagnosis of PD. In: Ahlskog, JE. Parkinson’s Disease Treatment Guide for Physicians. New York, NY: Oxford University Press; 2009:20-27.
Ahlskog JE. The Parkinson’s Disease Treatment Book: Partnering with Your Doctor to Get the Most from Your Medications. New York, NY: Oxford University Press; 2005:25-47